Canine found suffering from “anal ulceration“….
(Paige Freshwater) Experts have confirmed the first case of a dog with confirmed monkeypox virus infection in Paris, France that may have been acquired through human transmission – a family pet tested positive for the virus 12 days after its owners began to show symptoms.
A family dog has tested positive for monkeypox virus in what may be the first human-to-dog transmission case ever recorded. Researchers raised the alarm after an Italian greyhound contracted the virus 12 days after its owners began to show their onset symptoms.
Two men attended Pitié-Salpêtrière Hospital, in Paris, France, on June 10, after developing anal ulceration six days after having sex. One man had been experiencing anal ulceration and a rash on his face, ears, and legs, while the other developed a rash just on his legs and back.
Many men infected with monkeypox have reported a localized rash, often around the mouth, anus and genitals.
In both cases, the men experienced fatigue, headaches, and a fever four days after breaking out in a rash.
They had been co-sleeping with their dog – but said they have have been “careful to prevent their dog from contact with other pets or humans from the onset of their own symptoms”.
Despite their efforts, their dog tested positive for monkeypox virus after presenting “mucocutaneous lesions, including abdomen pustules and a thin anal ulceration”.
New research, published on The Lancet, a weekly peer-reviewed general medical journal, reads: “On July 23, 2022, monkeypox was declared a Public Health Emergency of International Concern by WHO Director-General Tedros Adhanom Ghebreyesus.
“Human-to-human transmission of monkeypox virus usually occurs through close contact with the lesions, body fluids, and respiratory droplets of infected people or animals.
“The possibility of sexual transmission is being investigated, as the current outbreak appears to be concentrated in men who have sex with men and has been associated with unexpected anal and genital lesions.”
The men had been co-sleeping with their dog before it tested positive for monkeyvirus
It’s still unknown if domesticated cats and dogs could be a vector for monkeypox – and the Lancet says this case may have been acquired through human transmission.
After testing the men for monkeypox, the virus was detected in skin and oropharynx samples for the first man, and in anal and oropharynx samples for the second.
“12 days after symptom onset, their male Italian greyhound, aged four years and with no previous medical disorders, presented with mucocutaneous lesions, including abdomen pustules and a thin anal ulceration,.” the study reads.
“The dog tested positive for monkeypox virus by use of a PCR protocol adapted from Li and colleagues that involved scraping skin lesions and swabbing the anus and oral cavity.
“Monkeypox virus DNA sequences from the dog and patient 1 were compared by next-generation sequencing (MinION; Oxford Nanopore Technologies, Oxford, UK).
“Both samples contained virus of the hMPXV-1 clade, lineage B.1, which has been spreading in non-endemic countries since April, 2022, and, as of Aug 4, 2022, has infected more than 1700 people in France, mostly concentrated in Paris, where the dog first developed symptoms.
“Moreover, the virus that infected patient 1 and the virus that infected the dog showed 100% sequence homology on the 19·5 kilobase pairs sequenced.”
The research was undertaken by Sophie Seang, Sonia Burre, Eve Todesco, Valentin Leducq, Gentiane Monsel, Diane Le Pluart, Christophe Cordevant, Valérie Pourcher, and Romain Palich – and was shared online on Wednesday.
It concludes: “To the best of our knowledge, the kinetics of symptom onset in both patients and, subsequently, in their dog suggest human-to-dog transmission of monkeypox virus.
“Given the dog’s skin and mucosal lesions as well as the positive monkeypox virus PCR results from anal and oral swabs, we hypothesise a real canine disease, not a simple carriage of the virus by close contact with humans or airborne transmission (or both).
“Our findings should prompt debate on the need to isolate pets from monkeypox virus-positive individuals. We call for further investigation on secondary transmissions via pets.”
As of August 8, there are 2,914 confirmed and 103 highly probable monkeypox cases in the UK, with 2,883 in England.
Dr William Welfare, incident director at UKHSA, said: “While the most recent data suggests the growth of the outbreak has slowed, we continue to see new cases every day.
“While anyone can get monkeypox, the majority of monkeypox cases in the UK continue to be in gay, bisexual and other men who have sex with men, with the infection being passed on mainly through close contact in interconnected sexual networks.
“Please continue to be aware of symptoms, including rashes and blisters, particularly if you have recently had a new sexual partner.”